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商品訊息描述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購買一定要買折價卷
台灣浩鼎生技5日凌晨在美國臨床腫瘤醫學會(ASCO)2016年會上進行口頭報告;生技業大老表示,這等於是「仙人指路」,將是全世界重大的焦點所在。
浩鼎今天在ASCO上宣佈,公司研發的乳癌新藥OBI-822/OBI-821(前為OPT-822/OPT-821),用於轉移性乳癌病患的臨床效益及免疫原性之二/三期研究數據,實驗結果,約50%對免疫療法能產生明顯免疫反應的病患次族群,其無惡化存活期(PFS)有顯著改善。
這位重量級業界人士分析,浩鼎這次發表會,等於告訴全世界「抗體」對癌症是有效的;而浩鼎採用的是透過疫苗施打讓病患本身產生抗體,進一步殺死癌細胞。
該疫苗是抗體加醣分子(Globo-H)的結合的合成醣蛋白,當疫苗進到人體後,會與授體結合(癌細胞內的醣分子),成為顯著的標耙,進一步會被免疫細胞殺死。
這位業界人士分析,從浩鼎公布的數據看來,證實了疫苗打下去會產生抗體,且對腫瘤有效;在50%有疫苗抗體反應的病患中,總存活期(OS)及無惡化存活期(PFS)都不錯,對四期癌末的病患而言,是「非常、非常、非常」有效的。他表示,癌症細胞對人體生命是有相當的催毀力,末期病人的免疫系統大多已失調,要產生抗體是困難的。
他強調,浩鼎這項臨床試驗的確是「科學上的大成功」,證實了Globo H對癌症有驚人的效果,這等於是「仙人指路」,告訴全世界「抗體」對癌症是有效的,未來對付腫瘤,以醣分子做為標耙將可更精準殺死癌細胞,這絕對會是「全世界重大焦點」,預計將在ASCO上掀起很大的震撼。
不過,有趣的是,這位業界大老特別聲明,這項實驗證實了是「翁啟惠成功了」,並非浩鼎成功,浩鼎只能說成功了第一步,因為浩鼎並沒有做「抗體」,浩鼎是做「疫苗」,必須透過疫苗啟動人體自身的抗體反應才能作用,疫苗即使不錯,但還是有50%的病患是沒有效的。
且OBI-822因這次的設計錯誤必須重新進入三期臨床試驗,一個試驗期就是2-3年的時間。不過,也有其他樂觀人士預期,整體試驗組和對照組OS的Pvalue隨著時間經過,有機會掉到0.05以下,時間可能發生在明年,OS一旦顯著,就有可能先和美國FDA溝通看看直接申請藥證的可能性。
既然知道抗體對腫瘤那麼有效,那除了以疫苗研發外,直接在體外以模擬生物反應器培養「抗體」,再直接以抗體打入人體對付癌細胞的治療方式將是另一途徑,且成功率預料將更高。這是浩鼎接下來必須面臨的競爭議題。
下面附上一則新聞讓大家了解時事
由失親兒基金會主辦的2016小星星繪畫比賽,今天(15日)舉行頒獎典禮,今年有191幅作品參賽,最終選出40幅得獎作品。失親兒基金會表示,未來將把得獎作品製成具有紀念價值的桌曆、帆布袋、手札等義賣品,一方面讓社會大眾能欣賞失親孩子的繪畫才華,同時也為失親兒基金會募集經費。
作品獲得國小低年級特優的「小妮」在四開的圖畫紙上,貼了好多顆色彩繽紛的愛心,她寫道:「愛可以用不完,所以我給很多愛心,可以給傷心的人、難過的人、不開心的人拿去用,讓他們有愛、有信、有望。」失親兒基金會指出,「小妮」年幼就失親,其實很缺乏愛,但卻在畫中願意分享愛,令人感動。
失親兒基金會執行長馮玉玲表示,藝術治療是諮商師常用的心理輔導方式,在孩子們內心深處無法用言語具體表達的傷痛,或對爸、媽的思念,可藉由畫畫的過程中,整理內心感受,並藉此表達夢想與感謝。
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